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At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.

OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. OpenEye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.; Cologne, Germany; and Tokyo, Japan.

We are looking for a Computational Chemist/Cheminformatician to join our team of experts in mathematics, computational modeling, and medicinal chemistry. This highly focused team will work together to drive forward technology which leverages OpenEye’s Orion platform to better enable scientists in the pharmaceutical industry working on projects from lead development to clinical candidate selection. This role will require interactions with customers and OpenEye’s scientific and technical teams.

What you’ll do:

• Extend OpenEye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.

• Explore methods for further enhancing OpenEye’s virtual screening platform (including OMEGA, ROCS, FastROCS, OEDocking).

• Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data-driven decision making.

• Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.

• Work with Orion project team to further optimize compound design workflows in Orion.

  What you should have:

• PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0 – 3 years relevant experience

• Knowledge of some traditional computational chemistry approaches such as docking, virtual screening, molecular modeling, etc.

• Programming expertise, ideally in c++ and/or python preferably with experience using AI coding agents

• Experience in or desire to learn about the pharmaceutical industry

• Strong desire to find practical solutions to challenging problems

• Demonstrated ability to work both as part of a team and independently

  The following are a PLUS, but not required:

• Experience with OpenEye software/toolkits

• Expertise with diffusion models, transformers or 3D ML representations

• Experience with synthetically accessible, pharmaceutically relevant generative chemistry

  Benefits: We are passionate about the welfare of our employees and offer competitive benefits that include medical, dental, vision, flexible working schedule, 401k retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement, and much more.

  Please submit your cover letter and resume as one document.

  OpenEye Scientific Software is an Equal Opportunity Employer.

  We’re doing work that matters. Help us solve what others can’t.

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Cadence plays a critical role in creating the technologies that modern life depends on. We are a global electronic design automation company, providing software, hardware, and intellectual property to design advanced semiconductor chips that enable our customers create revolutionary products and experiences.

Thanks to the outstanding caliber of the Cadence team and the empowering culture that we have cultivated for over 25 years, Cadence continues to be recognized by Fortune Magazine as one of the 100 Best Companies to Work For. 
 Our shared passion for solving the world’s toughest technical challenges, our dedication to pushing the limits of the industry, and our drive to do meaningful work differentiates the people of Cadence.

Cadence is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, basis of disability, or any other protected class.

Cadence is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, basis of disability, or any other protected class.