Job Information
Mount Sinai Health System Senior Associate Researcher - Hematology & Medical Oncology in New York, New York
Job Description
The Senior Associate Researcher will conduct research activities in collaboration with internal/external scientists/technicians and Post Docs to complete scientific-based project within the Division of Hematology/Medical Oncology. The laboratory focuses on stem cell biology of patients with myeloproliferative disorders.
The Senior Associate Researcher will independently conduct research experiments to support ongoing projects using advanced techniques, analyze and interpret highly complex results, and review and present data for publication and/or presentation. He/she will also assist postdoctoral fellows and students within the lab with their ongoing projects. The Senior Associate Researcher will report directly to the Principal Investigator (PI) of the program.
Qualifications
Bachelors Degree in sciences or related field. Masters Degree in sciences or related field preferred.
5 years in a research environment.
Preferred:
Science background
Experience in a research environment preferably with hematopoietic stem cells or primary human cell systems; extensive expertise in basic molecular and cellular biology methods including DNA and RNA isolation, siRNA methods, construct engineering, tissue culture and preparation and analysis of samples through flow cytometry platforms (including instrument setup, compensation design and analysis (e.g., using FlowJo, FCS Express, or similar software) of complex multicolor panels (≥8 colors).
Strong experience with biochemistry techniques including ELISA, Western blots and immuno-precipitations among others.
Previous experience in human hematopoietic stem/progenitor cell isolation, culture, and megakaryocyte-erythroid differentiation including immortalized cell lines.
Familiarity with cell signaling pathways, cytokine stimulation assays, and phospho-protein detection.
Excellent organizational and communication skills.
Effective teamwork as well as motivational supervision of others.
Reading and analytical skills; medical knowledge required.
Responsibilities
Conducts a variety of research experiments using advanced research techniques, performing basic molecular and cellular biology methods.
Perform isolation and culture of primary human hematopoietic stem and progenitor cells (CD34⁺) and other defined subsets from human mobilized peripheral blood or bone marrow.
Execute ex vivo differentiation assays for hematopoietic lineages, including morphological, molecular, and functional characterization.
Operate, maintain, and calibrate flow cytometer, including setup-optimize of multicolor panel design for complex immunophenotyping, cell sorting and quantification of hematopoietic subsets.
Perform methyl cellulose semisolid colony-forming assays and liquid culture systems for hematopoietic progenitors.
Perform protein-based assays, including protein extraction, Western blotting, ELISA, for pathway and signaling studies.
Conduct RNA and DNA extractions, RT-qPCR, and basic molecular biology techniques for gene expression and validation studies.Maintain accurate and organized experimental records, laboratory notebooks, and sample inventories.
Coordinates project activities to meet deadlines.
Collaborates with the Principal Investigator in the development of new experiments and research techniques. Incumbents are expected to stay apprised of the literature as well as practical skill sets relevant to the field.
Assists in the implementation of standardized protocols for experiments and training purposes; create and maintain Standard Operating Procedures (SOPs) specific for each study.
Mentors and trains less experienced research staff and graduate students in research techniques and use of equipment.
Ensures compliance with safety and regulatory requirements.
Performs other related duties.
About Us
Strength through Unity and Inclusion
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.
About the Mount Sinai Health System:
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation Statement
Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $61999 - $109583.67 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.