Job Information
University of North Carolina- Chapel Hill Research Assistant Professor in NC-Chapel-Hill, United States
Employment Type: Permanent Faculty
Vacancy ID: FAC0005837
Salary Range: Dependent on Qualifications
Position Summary/Description:
The Department of Cell Biology and Physiology at the UNC School of Medicine is recruiting for a fixed-term faculty position at the rank of Research Assistant Professor. This position will focus on creation and use of human brain organoid models for basic and translational studies related to ciliopathies. Conceptually and technically novel and innovative research focused on the mechanisms of primary cilia signaling in health and disease are expected. A major effort will be participating in the operation of the Anton Lab and development and implementation of novel technologies and cell biological models relevant to its mission of defining the mechanisms of early cerebral cortical development in the context of neurodevelopmental disorders. The position entails development and refinement of human organoid and mouse genetic models designed to define and manipulate primary cilia signaling in the developing neuronal and glial cells. The technologies involved may include latest advances in human cortical organoids, progenitor or neuron type specific mouse genetic models, live imaging, lineage tracing with bar codes, mapping of signaling interactomes, optogenetic and chemogenetic manipulation of primary cilia signaling, single cell genomics, CRISPR /Cas9 based genome editing, sequential proteomics of ciliary signaling networks, and functional evaluation of human mutations associated with neurodevelopmental disorders. The research areas will focus on neurodevelopmental disorders and the spectrum of models and technologies for their study. Additional duties will include participation in lab operation and management with a focus on staff collaboration. The development of independent research interests, funding, and publication in the scientific literature is highly desired.