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Department: 107200 Medical Affairs Location: San Diego, USA- Remote Be a part of a global team that is inspired to make a difference in the lives of people living with rare disease. At Travere Therapeutics, we recognize that our exceptional employees are vital to our success. We are a dedicated team focused on meeting the unique needs of rare patients.Our work is rewarding - both professionally and personally - because we are making a difference. We are passionate about what we do. We are seeking talented individuals who will thrive in our collaborative, diverse, fast-paced environment and share in our mission - to identify, develop and deliver life-changing therapies to people living with rare disease. We stick by our values centered on patients, courage, community, and collaboration to pursue our vision of becoming a leading biopharmaceutical company dedicated to the delivery of innovation and hope to patients in the global rare disease community. At Travere Therapeutics, we are in rare for life. We continue to courageously forge new paths as we move toward a common goal of elevating science and service for rare patients. Position Summary: The Sr. Medical Director, Integrated Evidence Generation - Nephrology will serve as the strategic architect of Travere's Medical Affairs-led evidence infrastructure. This role is responsible for defining and executing a multi-year integrated evidence strategy spanning post-approval interventional and non-interventional studies, investigator-sponsored research (ISR), collaborative research, real-world evidence (RWE), and lifecycle management (LCM). The Sr. Medical Director will chair the Evidence Generation Committee and act as the senior medical authority on post-approval and lifecycle evidence, partnering cross-functionally to strengthen Travere's scientific credibility and long-term asset value. In a growth-stage biotech environment, this role will also serve as a key member of the Nephrology Medical leadership and may contribute to broader TA priorities based on experience, expertise, and evolving organizational needs. The successful candidate must bring prior experience as a Medical Director, evidence generation leadership, deep knowledge of nephrology (preferred) and healthcare delivery, along with the ability to integrate these insights to shape Travere's Medical Affairs efforts. The ideal candidate will own evidence generation, drive strategic initiatives, support cross-functional partners, and foster external expert relationships, ensuring the success of Travere's nephrology portfolio. Key Responsibilities: Integrated Evidence & Lifecycle Strategy Define and lead a 3-5-year integrated evidence roadmap aligned to lifecycle and access priorities Serve as Medical Affairs evidence leads for LCM planning and execution Identify and address evidence gaps supporting label expansion, new subpopulations, combination strategies, durability, and long-term safety Ensure evidence strategy strengthens regulatory positioning and lifecycle business cases Partner with Clinical Development and Regulatory to align post-approval evidence with future development plans Evidence Governance & Investment Oversight Chair and govern the cross-functional Evidence Generation Committee Establish clear prioritization criteria and portfolio governance processes Oversee investment decisions across MA-led studies, ISR, collaborative research, and RWE Ensure evidence investments are strategically aligned to lifecycle objectives Provide executive-level updates to TA and GMA leadership ISR & Collaborative Research Strategy Establish and lead ISR governance framework within the TA Define scientific prioritization aligned to strategic data gaps Curate an ISR and collaborative research portfolio that advances guideline positi